Name : TRAIL/Apo2L, Human
Product Concentration :
Background :
TRAIL/Apo2L, also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10), is a pleiotropic cytokine thatbelongs to the TNF superfamily. The full length TRAIL expressed in vivo is a Type II transmembrane protein, although the soluble form also exists and functions. TRAIL has four major receptors: two death receptors DR4 and DR5, two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors, recruits the FAS-associated death domain, activates caspases 8 and 10, and eventually leads to apoptosis. Because of its antitumor potential, TRAIL is actively studied as a therapeutic agent. On the other hand, abnormal expression of TRAIL in small arteries can induce the proliferation of smooth muscle cells, resulting in increasing vascular remodeling and pulmonary arterial hypertension.
Biological Activity :
ED50 2.5 × 104 units/mg.
expression system :
E. coli
Tag :
Expressed with an N-terminal Met. TRAIL/Apo2L (Val114-Gly281)Accession # P50591
Protein Accession No. :
P50591
Synonyms :
TNF-related apoptosis-inducing Ligand; TNFSF10; Apo2 Ligand; TL2; CD_antigen: CD253; Protein TRAIL; Apo-2L
Molecular Weight :
~19.6 kDa, on SDS-PAGE under reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
Cardiotrophin-1/CTF1 Protein
BCA-1/CXCL13 Protein
Popular categories:
TPO-R/CD110
MMP-20