Name : IGF-I, Rat
Product Concentration :
Background :
Insulin-like Growth Factor I (IGF-I) is a single chain 7 kDa growth-promoting polypeptide originally identified as somatomedin-c. It belongs to the IGF family of peptides, which also includes IGF-II and insulin. The gene expression of IGF-I is mainly regulated by Growth Hormone, and IGF-I executes its functions via signaling through transmembrane tyrosine receptors (IGF Receptors). Most circulating IFG-I is associated with the IGF Binding Protein 3 (IGFBP-3), and the IGFBPs may inhibit the actions of IGFs by competing against the IGF Receptors. IGF-I is active in post-natal and adult animals, and is crucial for somatic growth, as IGF-I null mice show marked retardation in utero. IGF-I is involved in the carcinogenesis, and related to the prostate cancer as well.
Biological Activity :
ED50 1.0 × 105 units/mg.
expression system :
E. coli
Tag :
Expressed with an N-terminal Met. IGF-I (Gly49-Ala118)Accession # P08025
Protein Accession No. :
P08025
Synonyms :
Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Mechano growth factor; MGF; Insulin-like Growth Factor-I
Molecular Weight :
~7.8 kDa, on SDS-PAGE under reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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