Name : IGF-II, Human
Product Concentration :
Background :
Insulin-like Growth Factor II (IGF-II) is a single chain 7 kDa polypeptide, and shares a high degree of homology with Insulin. During circulation in vivo, IGF-II is complexed to high affinity binding proteins, IGF Binding Proteins (IGFBP), which act as circulating reservoirs, transport IGF-II, and prolong the half life of IGF-II. The receptors of IGF-II (IGFRs) are transmembrane tyrosine receptors, and are heterotetrameric consisting of two α-subunits and two β-subunits. IGFRs execute their role via intracellullar signaling molecules, such as IRS, shc, and PI3K. The functions of IGF-II include promoting cell survival, growth, proliferation, differentiation and motility. In particular, IGF-II promotes proliferation, inhibits death, and stimulates transformation in breast cancer cells.
Biological Activity :
ED50 5.0 × 104 units/mg.
expression system :
E. coli
Tag :
Expressed with an N-terminal Met. IGF-II (Ala25-Glu91)Accession # P01344-1
Protein Accession No. :
P01344-1
Synonyms :
Insulin-like Growth Factor-II; Somatamedin A
Molecular Weight :
~7.6 kDa, on SDS-PAGE under reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against 25 mM Tris, pH 8.0.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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