Name : IL-12, His, Rat

Product Concentration :

Background :
Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine composed of p35 and p40 subunits. It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens. IL-12 signals through the IL-12 receptor complex, which is comprised of IL-12 Rβ1 and IL-12 Rβ2. IL-12 induces the proliferation and activation of hematopoietic stem cells, natural killer cells and T- cells. It is indispensible during the development of Th1 cells, leading to the production of IFN-gamma and IL-2.

Biological Activity :
ED50

expression system :
CHO

Tag :
IL-12 p35 (Arg23-Ser215)Accession # Q9R103 Poly-His IL-12 p40 (Met23-Ser335)Accession # E9PU71 N-term C-term

Protein Accession No. :
Q9R103

Synonyms :
IL12; NKSF; TCMF; CLMF; TSF; CTL maturation factor; Cytotoxic lymphocyte maturation factor

Molecular Weight :
26~28 kDa (p35), 42~45 kDa (p40), on SDS-PAGE under reducing conditions.

Purity :
> 95% as analyzed by SDS-PAGE

Product Concentration :
Lyophilized after extensive dialysis against PBS.

Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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