Name : BCMA, Human
Product Concentration :
Background :
BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid extracellular domain.
Biological Activity :
Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40.0 ng/ml, corresponding to a specific activity of > 2.5 × 104 IU/mg in the presence of 100.0 ng/ml human APRIL.
expression system :
E. coli
Tag :
BCMA (Ala5-Ala54)Accession # Q02223
Protein Accession No. :
Q02223
Synonyms :
B-cell maturation protein; CD_antigen: CD269; TNFRSF17; BCM; Tumor necrosis factor receptor superfamily member 17
Molecular Weight :
Purity :
> 98% as analyzed by SDS-PAGE> 98% as analyzed by HPLC
Product Concentration :
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% TFA.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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